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- Instructor – Mt Sinai School of Medicine (2000-04)
- Post-Doctoral Fellow (EU-TMR) – University of Rome “La Sapienza” (1997-00)
- Post-Doctoral Scientist – R. W. Johnson Pharmaceutical Res. Institute (1995-97)
- Ph.D in Chemistry – University at Stony Brook (1994)
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Research Interests |
The principal focus of my research is to understand the function and dysfunction of proteins and macromolecular assemblies via modeling and simulation. The main topics can be broadly classified into three categories:
(1)Genes, proteins, structure, function and dynamics. The objective of these projects is to understand how the structure, including the genomic, primary, secondary and tertiary structure of a protein is related to its folding mechanism and to its dynamic and functional properties.
(2)Molecular recognition. The purpose of these projects is to characterize the dynamics and thermodynamics associated with molecular recognition processes in order to identify structural elements in proteins responsible for subfamily specificity and selectivity.
(3) Allosteric regulation and signal transduction . The focus of these projects is to identify structural elements in proteins that transmit allosterically via structural and dynamical changes information such as the binding of a ligand or a protein. The aim is to identify putative regulatory sites that can be exploited to interfere or enable protein-protein interactions for therapeutic intervention or elucidation of signal transduction pathways. |
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