$2.5M award to help make CSI biotech center

- Staten Island Advance, October 25, 2002 by Diana Yates of STATEN ISLAND ADVANCE

State grant will allow school to expand research programs in medicine, agriculture

         A $2.5 million state award will help create a major biotechnology research institute at the College of Staten Island, state Sen. John Marchi and Dr. Marlene Springer, the college president, have announced.

        Dr. Springer heralded the award - garnered with Marchi’s help - as " a momentous occasion for the College of Staten Island". The new center, called the Macromolecular Assemblies Institute, will contribute to advances in medicine and agriculture, and may even be important to efforts to combat bioterrorism.

        The money comes from a $225 million state fund, called The Gen-NY-sis (Generating Employment for New York Science), which is designed to expand the state’s biotechnology-research industry.

        "I think it speaks well of the Senator and I that we are supportive of an institute it took a while to learn to pronounce," Dr. Springer laughingly told a room of scientists, administrators and deans gathered Wednesday at the Willowbrook campus. On a more serious note, she said the award is a formal recognition of the value of the research already under way at CSI, and will help the college fund and extend that research.

INVESTMENT IN FUTURE

        The investment in biotech research will bring many local profits, but has implications and Staten benefits, but has implications beyond Staten Island’s border, Marchi said. "This is an area of maximum concern and sensitivity," he said, "not only in the ,but federally."

        The $2.5 million is only the first installment of a larger commitment he hoped to ex-tract from the state, Marchi told Dr. Springer. You ain’t seen nothing yet,he said.

        Dr. Ruth E. Stark, a veteran researcher at CSI and head of its nuclear magnetic resonance facility, will head the institute. She earned her Ph.D. in physical chemistry at the University of California, San Diego, and obtained postdoctoral training in molecular bi-ophysics at Massachusetts Institute of Technology, Cambridge. She teaches genneral and physical chemistry at CSI, and has co-directed the City University of New York’s Center for Applied Biomedicine and Biotechnology.

        The money will give the college the momentum it needs to build a world-class research facility, Dr. Stark said. The simple thing would be to take the money and to make good use of it, she said. But the better thing is to build on it for the future. While the money is ear-marked for capital costs, such as laboratories and equipment, it will also enhance CSI’s reputation, which will bring in more funding and attract scientists who are leaders in their fields, Dr. Stark said.

THE MACHINES OF LIFE

        As its title implies, the new institute will focus on the interaction of large molecules which in the body or a test tube assemble themselves into organized structures. These assemblies are the basic machines that drive all life: The cell itself is an as-sembly of molecules that in-teract in specific ways.

        The outer protein skin of the HIV virus is an assembly, as is the receptor on the sur-face of a human cell to which the virus binds during infec-tion. By examining the structure and function of these assem-blies, scientists hope to tease out the underlying mecha-nisms of healing and disease. They may also learn how to fabricate new assemblies, such as vaccines, that hinder she structures that contribute to disease. Much of this work involves simply trying to see the molecules and how they bind together, said Dr. Stark. For that, researchers need a host of sophisticated tools. The grant will allow the college to get much-needed equipment and build new laboratories to aid the work. Scientists at CSI are al-ready studying macromole-cular assemblies implicated in many diseases or possibly valuable in disease treatment. Dr. Stark is studying the assembly of proteins associated with Parkinson’s disease. Other research may lead to new ways to deliver drugs to specific locales in the body, enhance the effectiveness of existing drugs or lessen the body’s rejection of trans-planted organs. Some fields of study may help develop methods for detecting or removing biologically or chemically hazardous materials. The research is valuable in its own right, but is also fundamental to the educational goals of the college, Dr. Stark noted. I know I can’t spend all my time in the classroom and still do my research, she said. But when I’m in the classroom I’m giving 110 percent. And I also bring my research into the classroom. Educating students in a reputable research setting exposes them to top-notch scientists and cutting edge ideas, Dr. Stark said, which enhances their knowledge and broadens their opportunities.